What are the objectives of medical treatment of MDMA toxicity?

Updated: May 30, 2020
  • Author: In-Hei Hahn, MD, FACEP, FACMT; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Objectives in pharmacotherapeutic intervention of MDMA toxicity include the following:

  1. Decontamination with activated charcoal/sorbitol
  2. Sedation with benzodiazepines in agitated and anxious patients
  3. Relief of muscle spasms and/or cramping with benzodiazepines
  4. Prevention of rhabdomyolysis with IV fluids (benefit of furosemide or sodium bicarbonate remains controversial)
  5. Seizure control with benzodiazepines
  6. Stabilization of hemodynamic and/or cardiovascular disturbances with nitroprusside or nitroglycerin.

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