What causes morbidity in MDMA toxicity?

Updated: May 30, 2020
  • Author: In-Hei Hahn, MD, FACEP, FACMT; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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While most patients with MDMA overdose improve with supportive care, life-threatening complications may result from severe toxicity. Fatalities have been reported because of severe hyperthermia (ie, heat stroke) accompanied by disseminated intravascular coagulation, rhabdomyolysis, and acute renal failure. Death from cerebral edema and seizures secondary to hyponatremia and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) has also been reported. As in any amphetamine toxicity, the danger of cardiac arrhythmias and cardiovascular instability always must be entertained.

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