What are the genitourinary and dental signs and symptoms of MDMA toxicity?

Updated: May 30, 2020
  • Author: In-Hei Hahn, MD, FACEP, FACMT; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Other manifestations include the following:

  • Urinary retention, difficulty voiding
  • Sexual dysfunction
  • Dental - Bruxism (jaw clenching) is frequently observed in MDMA users; it results in enamel erosion and dental decay, with consequent tooth fracture and gum recession.

Although the causal relationship between MDMA and liver toxicity has not been shown definitively, case reports document hepatotoxicity resulting in self-limited hepatitis and fulminant liver failure following MDMA use. Always keep in mind the possibility of other drug ingestions. MDMA users often co-ingest other drugs, and ecstasy tablets can also contain other drugs. Heroin, ketamine, cocaine, alcohol, and marijuana have been implicated, and the patient may present with a mixed toxidromic clinical picture.

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