Which medications in the drug class Blood Components are used in the treatment of Warfarin and Superwarfarin Toxicity?

Updated: Jan 19, 2018
  • Author: Kent R Olson, MD, FACEP; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Blood Components

Fresh frozen plasma (FFP) has been the mainstay for urgent anticoagulation reversal in patients taking vitamin K antagonists (eg, warfarin). FFP requires blood group typing and thawing before use. Unlike plasma, human prothrombin complex concentrate does not require blood group typing or thawing and is administered in a significantly lower volume than plasma. Prothrombin does have a slightly higher risk for thromboembolic (TE) events compared with plasma, particularly in patients with a history of TE events.

Fresh frozen plasma

Each unit provides all plasma proteins and clotting factors to support adequate hemostasis to treat bleeding.

Prothrombin complex concentrate, human (Kcentra)

Contains Factors II, VII, IX, X, Protein C and S. It is indicated for urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist therapy in adults with acute major bleeding.


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