Which conditions should be considered in the differential diagnoses of warfarin and superwarfarin toxicity?

Updated: Jan 19, 2018
  • Author: Kent R Olson, MD, FACEP; Chief Editor: David Vearrier, MD, MPH  more...
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Conditions to consider in the differential diagnosis of warfarin or superwarfarin toxicity include the following:

  • Type A hemophilia

  • Type B hemophilia

  • Munchausen syndrome

  • Munchausen syndrome by proxy

  • Child abuse

  • Epistaxis

  • GI bleeding

  • Ectopic pregnancy

  • Postpartum hemorrhage

  • Hemorrhagic shock

  • Hypovolemic shock

  • Hemorrhagic stroke

  • Subarachnoid hemorrhage

  • Subdural hematoma

  • Vitreous hemorrhage

  • Liver failure

  • Factor X deficiency

  • Factor V deficiency

  • Afibrinogenemia

  • Dysfibrinogenemia

  • Vitamin K deficiency

  • Malabsorptive states

  • Domestic violence

  • Retroperitoneal hemorrhage

Prolonged prothrombin time (PT) and partial thromboplastin time (PTT) followed by demonstration of specific deficiency of vitamin K–dependent blood coagulation protein activities narrows the diagnostic possibilities. [12]

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