Which physical findings are characteristic of warfarin and superwarfarin toxicity?

Updated: Jan 19, 2018
  • Author: Kent R Olson, MD, FACEP; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Do not expect to see physical evidence of bleeding after an acute ingestion for at least 24 hours. Life-threatening complications include massive GI bleeding and intracranial hemorrhage. More common findings of excessive anticoagulation are ecchymoses, subconjunctival hemorrhage, epistaxis, vaginal bleeding, bleeding gums, or hematuria.

In all patients, if prolongation of the PT is observed after an acute ingestion, it may appear in as early as 8-12 hours; however, peak effects commonly are delayed until at least 1-2 days postingestion.


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