What are the possible adverse reactions to chronic warfarin therapy?

Updated: Jan 19, 2018
  • Author: Kent R Olson, MD, FACEP; Chief Editor: David Vearrier, MD, MPH  more...
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Other adverse reactions that occur infrequently with chronic warfarin therapy include the following:

  • Agranulocytosis

  • Alopecia

  • Anaphylactoid reactions

  • Anorexia

  • Cold intolerance

  • Diarrhea

  • Dizziness

  • Elevated hepatic enzyme levels

  • Exfoliative dermatitis

  • Headache

  • Hepatitis

  • Jaundice

  • Leukopenia

  • Nausea and/or vomiting

  • Pruritus

  • Urticaria

Rare events of tracheal or tracheobronchial calcification have been reported in association with long-term warfarin therapy. The clinical significance is not known. Priapism is associated with anticoagulant administration; however, a causal relationship with warfarin is not established.

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