Which medications interfere with protein binding and increase the risk for warfarin and superwarfarin toxicity?

Updated: Jan 19, 2018
  • Author: Kent R Olson, MD, FACEP; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Drugs that interfere with protein binding include the following:

  • Chloral hydrate
  • Clofibrate
  • Diazoxide
  • Ethacrynic acid
  • Miconazole (including intravaginal use)
  • Nalidixic acid (displaces protein binding)
  • Salicylates
  • Sulfonamides
  • Sulfonylureas

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