Which medications in the drug class Sedatives are used in the treatment of Methamphetamine Toxicity?

Updated: Oct 29, 2020
  • Author: John R Richards, MD, FAAEM; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Neuroleptic agents are CNS dopamine antagonists that are useful for control of agitated patients. By increasing the action of GABA, which is a major inhibitory neurotransmitter in the brain, benzodiazepines depress all levels of CNS, including limbic and reticular formation. Haloperidol and droperidol are D2 receptor antagonists that interfere with dopaminergic neurotransmission in the limbic system and the cerebral cortex.

Lorazepam (Ativan)

Benzodiazepine. GABA receptor agonist.

Diazepam (Valium)

Benzodiazepine. GABA receptor agonist.

Midazolam (Versed)

Benzodiazepine. GABA receptor agonist.

Haloperidol (Haldol)

CNS dopamine D2 receptor antagonist.

Droperidol (Inapsine)

CNS dopamine D2 receptor antagonist.

Olanzapine (Zyprexa, Zydis)

The exact mechanism of action of olanzapine is not known. It binds to alpha-1, dopamine, histamine H-1, muscarinic, and serotonin type 2 (5-HT2) receptors.

Ziprasidone (Geodon)

Dopamine and serotonin receptor antagonist. It also inhibits the re-uptake of serotonin and norepinephrine in the CNS.

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