How are renal function tests used in the workup of acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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Renal function tests (ie, electrolyte, blood urea nitrogen [BUN], and creatinine concentrations) can reveal evidence of co-existing renal failure and hepatorenal syndrome. [29] An elevated serum creatinine concentration is also a predictor of mortality. Urinalysis showing proteinuria and hematuria may indicate acute tubular necrosis.

Renal injury becomes apparent 2-3 days after an acute acetaminophen ingestion (phase 2). Rarely, renal failure can occur independently of hepatic failure. [30] One study indicated that this is more likely to occur in persons who have history of ethanol abuse.

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