Which conditions should be considered in the DDX of acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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When evaluating a patient with suspected acetaminophen toxicity, also consider other conditions that can cause acute hepatotoxicity or have a similar clinical presentation. The following conditions should be considered as part of the possible differential diagnosis:

  • Drug-induced or toxin-induced hepatitis

  • Hepatobiliary disease

  • Hepatorenal syndrome

  • Inborn errors of metabolism, including alpha1-antitrypsin (AAT) deficiency or fatty acid oxidation abnormalities

  • Reye syndrome

  • Viral hepatitis due to Epstein-Barr virus or varicella

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