What are the risk factors for chronic acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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Answer

In chronic acetaminophen toxicity, the role of fasting, reduced glutathione stores, and enhanced metabolism remains unclear. Risk factors for chronic acetaminophen toxicity include the following [19] :

  • Repeated administration of high doses
  • Repeated administration of proper doses at shortened time intervals
  • Fever
  • Poor oral intake
  • Young age (as due to caregiver mismanagement)

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