What are the minimum toxic acetaminophen dosages in adults and children?

Updated: Jan 22, 2018
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
  • Print
Answer

In adults, the minimum toxic dose of acetaminophen for a single ingestion is 7.5-10 g. In children, the minimum toxic dose of APAP for a single acute ingestion is 150 mg/kg.

In healthy children aged 1-6 years, medical toxicologists recommend increasing this threshold to 200 mg/kg. Children in this age group are less susceptible to hepatotoxicity from acute acetaminophen poisoning. Differences in medication metabolism within this age group and a relatively larger hepatic mass (ie, ratio of organ weight to total body weight) may both play roles in more efficiently detoxifying and eliminating NAPQI.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!