Which medications and agents increase the risk of acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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In addition, the production of NAPQI (and thus the risk of hepatocellular injury) is increased by activation of the hepatic cytochrome system. Agents and medications that induce CYP enzyme activity are numerous, and include some of the following:

  • Ethanol ingestion
  • Tobacco smoking
  • Isoniazid (INH)
  • Rifampin
  • Phenytoin
  • Phenobarbital
  • Barbiturates
  • Carbamazepine
  • Trimethoprim-sulfamethoxazole (TMP-SMZ)
  • Zidovudine

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