When is the IV formulation of N -acetylcysteine (NAC) preferred in the treatment of acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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The IV formulation of NAC (Acetadote) is commonly used in many institutions for the treatment of acetaminophen ingestion. Use of the IV formulation of NAC is preferred in the following situations:

  • Altered mental status

  • GI bleeding and/or obstruction

  • A history of caustic ingestion

  • Potential toxicity in a pregnant woman

  • Inability to tolerate oral NAC because of emesis refractory to proper use of antiemetics

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