What is the dosage regimen of N -acetylcysteine (NAC) for the treatment of acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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The FDA-approved regimen for oral administration of NAC (Mucomyst) is as follows:

  • Loading dose of 140 mg/kg

  • 17 doses of 70 mg/kg given every 4 hours

  • Total treatment duration of 72 hours

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