What are the recommended serum studies in the workup of acetaminophen toxicity/poisoning?

Updated: Jan 17, 2020
  • Author: Susan E Farrell, MD; Chief Editor: Michael A Miller, MD  more...
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Recommended serum studies are follows:

  • Liver function tests (alanine aminotransferase [ALT], aspartate aminotransferase [AST]), bilirubin [total and fractionated], alkaline phosphatase)

  • Prothrombin time (PT) with international normalized ratio (INR)

  • Glucose

  • Renal function studies (electrolytes, BUN, creatinine)

  • Lipase and amylase (in patients with abdominal pain)

  • Human chorionic gonadotropin (hCG) (in females of childbearing age)

  • Salicylate level (in patients with concern of co-ingestants)

  • Arterial blood gas and ammonia (in clinically compromised patients)

Additional recommended studies are as follows:

  • Urinalysis (to check for hematuria and proteinuria)

  • ECG (to detect additional clues for co-ingestants)

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