What are the physiologic mechanisms of carbon monoxide (CO) toxicity?

Updated: Sep 18, 2018
  • Author: Guy N Shochat, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Answer

CO can produce direct cellular changes involving immunological or inflammatory damage by a variety of mechanisms, including the following [3] :

  • Binding to intracellular proteins (myoglobin, cytochrome a,a3)

  • Nitric oxide generation leading to peroxynitrite production

  • Lipid peroxidation by neutrophils

  • Mitochondrial oxidative stress

  • Apoptosis

  • Immune-mediated injury

  • Delayed inflammation


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