What are the signs and symptoms of acute vitamin E toxicity?

Updated: Jun 01, 2020
  • Author: Mark Rosenbloom, MD, MBA; Chief Editor: Michael A Miller, MD  more...
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The effects of acute vitamin E toxicity include the following:

  • Nausea
  • Gastric distress
  • Abdominal cramps
  • Diarrhea
  • Headache
  • Fatigue
  • Easy bruising and bleeding - Prolonged PT and activated partial thromboplastin time (aPTT)
  • Inhibition of platelet aggregation
  • Diplopia - At dosages as low as 300 IU
  • Muscle weakness
  • Creatinuria

Chronic toxicity effects include all of the above, as well as suppression of other antioxidants and increased risk of hemorrhagic stroke.

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