What are the signs and symptoms of chronic vitamin D toxicity?

Updated: Jun 01, 2020
  • Author: Mark Rosenbloom, MD, MBA; Chief Editor: Michael A Miller, MD  more...
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Chronic toxicity effects include the above symptoms, as well as the following:

  • Constipation
  • Abdominal cramps
  • Polydipsia
  • Polyuria
  • Backache

Findings may also include calcinosis, followed by hypertension and cardiac arrhythmias (due to a shortened refractory period).

In case reports of two young breast-fed infants who developed vitamin D toxicity from inadvertent overdose of highly concentrated vitamin D formulations,  the infants presented with decreased feeding, lethargy, and inconsolable crying. Toddlers with vitamin D overdose have presented with irritability, vomiting, constipation, and hypertension. [43]

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