How does the prevalence of vitamin toxicity vary by age?

Updated: Jun 01, 2020
  • Author: Mark Rosenbloom, MD, MBA; Chief Editor: Michael A Miller, MD  more...
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Single vitamins are consumed more often by adults, while multivitamins are administered more frequently to children. 

Premature infants with low birthweight have suffered life-threatening adverse effects from vitamin E, with sepsis and necrotizing enterocolitis having occurred in these infants but not in others.

A syndrome of ascites, hepatomegaly, and thrombocytopenia resulting in death occurred in the 1980s in association with an intravenous vitamin E preparation used in premature infants with low birthweight. The cause was presumably a polysorbate carrier of the vitamin, and the syndrome has not occurred since its removal.

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