What is the prevalence of vitamin toxicity in the US?

Updated: Jun 01, 2020
  • Author: Mark Rosenbloom, MD, MBA; Chief Editor: Michael A Miller, MD  more...
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The Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS) documents the number of exposures for each class of vitamins (eg, adult and pediatric multiple vitamins, individual vitamins), the outcomes, and the fatalities from that ingestion. [1, 2]  In 2018, the NPDS reported 48,630 single exposures to vitamins, with 1697 minor adverse outcomes, 189 moderate outcomes, 5 major outcomes (2 of them involving vitamin D), and no deaths. [1]

Regarding vitamin D toxicity, a retrospective analysis of NPDS data from 2000 through June 30, 2014 found that the mean number of exposures, which was 196 per year from 2000 to 2005, increased 1600% between 2005 and 2011 to a new annual mean of 4535 exposures per year. Nevertheless, a decline occurred in the percentage of patients treated in a health care facility and of patients with serious medical outcome, and no deaths were reported. [40]

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