What is the role of lab tests in the workup of opioid toxicity?

Updated: Jul 19, 2021
  • Author: Everett Stephens, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Answer

Drug screens are widely available but rarely alter clinical management in uncomplicated overdoses. Drug screens are most sensitive when performed on urine. Positive results are observed up to 36-48 hours postexposure, but wide variations are possible depending upon test sensitivity, dose, route, and the patient's metabolism.

In patients with moderate-to-severe toxicity, performing the following baseline studies is appropriate:

  • Complete blood cell count
  • Comprehensive metabolic panel
  • Creatine kinase level
  • Arterial blood gas determinations

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