What are the clinical features of stage 3 iron toxicity?

Updated: Feb 04, 2019
  • Author: Clifford S Spanierman, MD; Chief Editor: Michael A Miller, MD  more...
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Features of stage 3 iron toxicity are as follows:

  • Stage 3 is characterized by metabolic acidosis and cardiovascular symptoms; the acidosis may indicate failure of organs such as the heart and kidneys

  • It is hypothesized that high iron concentrations produce venous pooling and third-spacing of fluids

  • Central nervous system (CNS) symptoms, usually stupor and coma, are also characteristic of stage 3

  • Most deaths occur during this stage

  • Stage 3 can start very early (6-8 h), depending on severity of exposure, and can last up to 2 days

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