Which medications in the drug class Nutrients are used in the treatment of Ethylene Glycol Toxicity?

Updated: Dec 05, 2017
  • Author: Daniel C Keyes, MD, MPH; Chief Editor: Sage W Wiener, MD  more...
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Answer

Nutrients

Pyridoxine enhances metabolism of glyoxylate to glycine. Thiamine catalyzes metabolism of glyoxylate from glycolic acid. Vitamin therapy is a safe and reasonable adjunct in patients with ethylene glycol poisoning. Regional poison centers may suggest the use of these therapies in certain cases.

Pyridoxine (Nestrex)

Water-soluble vitamin B6, which is a cofactor in conversion of GA to nonoxalate compounds. Involved in synthesis of GABA within CNS.

Thiamine (Thiamilate)

Vitamin B-1 is water-soluble and used in many cellular functions that involve energy formation and use. Promotes conversion of glyoxylate to a nontoxic metabolite, alpha-hydroxy-beta-ketoadipate.


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