Which medications in the drug class Benzodiazepines are used in the treatment of Medication-Induced Dystonic Reactions?

Updated: Feb 19, 2018
  • Author: John Michael Kowalski, DO; Chief Editor: David Vearrier, MD, MPH  more...
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Normal balance between dopamine and acetylcholine in the basal ganglia involves modulation from GABA-containing striatonigral neurons. GABA-ergic neurons are inhibitory and antagonize excitatory dopaminergic neurons. GABA agonists (eg, benzodiazepines) may be helpful for acute dystonic reactions when anti-muscarinic agents are not approporiate.

Diazepam (Valium)

Some recommend using diazepam for patients with dystonic reactions refractory to anticholinergic therapy or when such therapy is contraindicated.

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