Which clinical history is characteristic of medication-induced dystonic reactions?

Updated: Feb 19, 2018
  • Author: John Michael Kowalski, DO; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Dystonic reactions most often occur shortly after initiation of drug treatment or an increase in drug dose; 50% occur within 48 hours of initiation of treatment, and 90% occur within 5 days. A literature review by Hawthorne and Caley found among published reports of extrapyramidal reactions associated with serotonergic antidepressant therapy—not only dyskinesia but also akathisia, dyskinesia, parkinsonism, and mixed extrapyramidal reactions—that the reactions typically developed within 30 days of either the start of treatment or a dosage increase. [7]


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