How is cocaine toxicity prevented?

Updated: Dec 31, 2020
  • Author: Lynn Barkley Burnett, MD, EdD, JD; Chief Editor: Sage W Wiener, MD  more...
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Experimental studies in animals indicate that circulating cocaine can be sequestered by high levels of anticocaine antibodies, thereby facilitating inactivation of the cocaine prior to its entry into the brain, via the action of natural plasma cholinesterase. While the US Food and Drug Administration has not approved any prophylactic pharmacotherapies for cocaine abuse, research using a cocaine-specific vaccine is in the early stages. Using succinylnorcocaine covalently linked with an immunogenic carrier, changes in IgG anticocaine antibody levels have demonstrated response kinetics similar to those of the human conjugate vaccine for nicotine. [65]

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