What is the clinical presentation of phase II (advanced stimulation) cocaine toxicity?

Updated: Dec 31, 2020
  • Author: Lynn Barkley Burnett, MD, EdD, JD; Chief Editor: Sage W Wiener, MD  more...
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Phase II (advanced stimulation) is as follows:

  • CNS findings - Malignant encephalopathy, generalized seizures and status epilepticus, decreased responsiveness to all stimuli, greatly increased deep tendon reflexes, and incontinence

  • Circulatory findings - Hypertension; tachycardia; and ventricular dysrhythmias (possible), which then result in weak, rapid, irregular pulse and hypotension; and peripheral cyanosis

  • Respiratory findings - Tachypnea, dyspnea, gasping, and irregular breathing pattern

  • Temperature - Severe hyperthermia (possible)

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