What are the neurologic and psychiatric signs and symptoms of cocaine toxicity?

Updated: Dec 31, 2020
  • Author: Lynn Barkley Burnett, MD, EdD, JD; Chief Editor: Sage W Wiener, MD  more...
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In short, neurologic and psychiatric findings may include the following:

  • Normal sensorium

  • Altered mental status (a change in the level of consciousness or the content of consciousness)

  • Confusion

  • Restlessness

  • Severe agitation

  • An increase in purposeless psychomotor activity that may be exacerbated by nonspecific stimulation in the setting of cocaine use (commonly called cocaine leaps)

  • "Overamped" or "wired" behavior (agitation)

  • Paranoia

  • Delirium (a florid abnormal mental state characterized by disorientation, fear, and irritability with misperception of sensory stimuli)

  • Headache

  • Tremor

  • Depression and extreme exhaustion associated with withdrawal following a binge

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