What are the sexual predispositions of cocaine toxicity?

Updated: Dec 31, 2020
  • Author: Lynn Barkley Burnett, MD, EdD, JD; Chief Editor: Sage W Wiener, MD  more...
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In DAWN reports for 2011, men accounted for 325,396 cocaine-related ED visits, and women, 179,520. [1] This disparity may have a physiologic basis.

On a milligram-per-kilogram basis, women who use cocaine intranasally have significantly lower plasma cocaine levels than men. Women using cocaine in the luteal phase of their menstrual cycle have peak plasma levels lower than those observed during the follicular phase of the cycle. [25] Notwithstanding these differences, be mindful of the potential for increased cocaine cardiotoxicity in women previously discussed (see the Pharmacology section in Background).

Men detect the effects of cocaine faster and report more episodes of euphoria and of dysphoria than women.

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