What are the signs and symptoms of phase III (depression and premorbid) cocaine toxicity?

Updated: Sep 01, 2018
  • Author: Lynn Barkley Burnett, MD, EdD, LLB(c); Chief Editor: Sage W Wiener, MD  more...
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Phase III (depression and premorbid state) is as follows:

  • CNS: Coma, areflexia, pupils fixed and dilated, flaccid paralysis, and loss of vital support functions

  • Circulatory: Circulatory failure and cardiac arrest (ventricular fibrillation [VF] or asystole)

  • Respiratory: Respiratory failure, gross pulmonary edema, cyanosis, agonal respirations, and paralysis of respiration

See Presentation for more detail.

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