What are nonselective beta-blockers?

Updated: May 30, 2020
  • Author: Adhi Sharma, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Propranolol was the first beta-blocker to enter widespread use; much of the clinical and overdose experience that exists with beta-blockers was provided by case reports and clinical studies of this drug. Propranolol is a nonselective beta-blocker, demonstrating equal affinity for both beta1- and beta2-receptors. Other nonselective beta-blockers include nadolol, timolol, and pindolol. Nonselective beta-blockers exert a wider variety of extracardiac manifestations.

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