What are the potential complications from overdoses of fibrinolytic agents used in thrombolytic therapy?

Updated: Dec 31, 2017
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
  • Print
Answer

Answer

Overdoses of fibrinolytic agents can cause severe hemorrhagic complications. Overdose most often occurs when a full dose of a fibrinolytic agent is given to a small patient with a low body weight.

In patients receiving fibrinolysis for acute myocardial infarction (AMI), the overall incidence of hemorrhagic complications is about 10%, and the incidence of ICH is about 0.8%. In patients receiving fibrinolysis for AIS, the incidence of ICH is higher, approximately 6%.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!