What is the role of intra-arterial thrombolysis in the treatment of acute ischemic stroke (AIS)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
  • Print


An alternative to systemic thrombolysis is local intra-arterial thrombolysis using a lower dose. Endovascular techniques have been used for achieving acute revascularization after ischemic stroke within a longer therapeutic window from symptom onset. At present, no drugs are approved by the FDA for intra-arterial treatment of AIS, and such therapy is not standard.

Intra-arterial thrombolysis is an option for treatment of selected patients who can be treated within 3-6 hours after the onset of symptoms due to occlusion of the middle cerebral artery and who are not otherwise candidates for IV tPA. [59, 60, 61]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!