What is the role of catheter-directed thrombolysis (CDT) in the thrombolytic therapy of deep vein thrombosis (DVT)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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CDT is performed under imaging guidance; the procedure delivers the thrombolytic agent directly to the clot through a catheter inserted in the vein. Intraclot injection of the thrombus with a fibrin-specific thrombolytic agent is an alternative to continuous infusion and minimizes the duration of systemic exposure to thrombolytic agents.

A retrospective study that compared the efficacy and safety of urokinase, alteplase, and reteplase in CDT for the treatment of symptomatic DVT concluded that the three thrombolytic agents had similar success and complication rates. [36] In another study, tenecteplase was reported to achieve significant or complete lysis in 83.3% of cases. [37]

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