What is the FDA recommended regimen of urokinase for thrombolytic therapy of pulmonary embolism (PE)?

Updated: Dec 31, 2017
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Answer

Answer

The FDA-approved urokinase regimen for PE consists of 4400 U/kg as a loading dose given at a rate of 90 mL/hr over a period of 10 minutes, followed by continuous infusion of 4400 U/kg/hr at a rate of 15 mL/hr for 12 hours.


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