Why are fast-acting agents preferred for thrombolytic therapy for pulmonary embolism (PE)?

Updated: Dec 31, 2017
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Answer

Answer

Patients with pulmonary thromboembolism often decompensate suddenly, and once hemodynamic compromise has developed, mortality is extremely high. When the decision is made to use thrombolysis, the fastest-acting available thrombolytic agent with an acceptable safety and efficacy profile should be chosen. Many centers prefer off-label regimens to the slower on-label regimens that have been approved by the US Food and Drug Administration (FDA).


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