What are the thrombolytic therapy regimens for tenecteplase in patients with acute myocardial infarction (AMI)?

Updated: Dec 31, 2017
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Answer

Answer

To reconstitute tenecteplase, mix the 50-mg vial in 10 mL sterile water (5 mg/mL). Tenecteplase is administered in a 30-50 mg IV bolus over 5 seconds. The dosage is calculated on the basis of the patient’s weight, as follows:

  • <60 kg - 30 mg (6 mL)
  • 60 to 69 kg - 35 mg (7 mL)
  • 70 to 79 kg - 40 mg (8 mL)
  • 80 to 89 kg - 45 mg (9 mL)
  • ≥90 kg - 50 mg (10 mL)

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