What are the thrombolytic therapy regimens for reteplase in patients with acute myocardial infarction (AMI)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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First, reconstitute two 10-unit vials with sterile water (10 mL) to 1 U/mL. The adult dose of reteplase for AMI consists of two IV boluses of 10 units each; there is no weight adjustment. The first 10-unit IV bolus is given over 2 minutes; 30 minutes later, a second 10-unit IV bolus is given over 2 minutes. Administer normal saline (NS) flush before and after each bolus.

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