What is the mechanism of action for anisoylated purified streptokinase activator complex (APSAC) in thrombolytic therapy?

Updated: Dec 31, 2017
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Answer

Answer

APSAC (anistreplase) is a complex of streptokinase and plasminogen that does not require free circulating plasminogen to be effective. It has many theoretical benefits over streptokinase but suffers antigenic problems similar to those of the parent compound. Like streptokinase, anistreplase does not distinguish between fibrin-bound and circulating plasminogen; consequently, it too produces a systemic lytic state. The half-life of APSAC in plasma is somewhere between 40 and 90 minutes.


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