What are the components of a blood clot targeted by thrombolytic therapy?

Updated: Dec 31, 2017
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Answer

Answer

The three main components of a blood clot are as follows:

  • Platelets
  • Thrombin
  • Fibrin

Each of these components is a key therapeutic target. During thrombus formation, circulating prothrombin is activated to the active clotting factor, thrombin, by activated platelets. Fibrinogen is activated to fibrin by the newly activated thrombin. Fibrin is then formed into the fibrin matrix. All this takes place while platelets are being adhered and aggregated.


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