What is the difference in mortality between high and low levels of PEEP in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)?

Updated: Apr 07, 2020
  • Author: Allon Amitai, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Answer

A recent meta-analysis that compared high versus low levels of PEEP in patients with ALI and ARDS found no difference in mortality before hospital discharge amongst studies that used the same tidal volume in both control and intervention arms. [17] In a subsequent subgroup analysis that assessed lung-protective ventilation (low tidal volume, high PEEP) versus conventional mechanical ventilation, the authors found a decrease in mortality with the use of a lung-protective ventilation strategy. The same review also found that high levels of PEEP do improve oxygenation in patients with ALI and ARDS.


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