What causes histoplasmosis pneumonia in immunocompromised patients?

Updated: Jan 07, 2019
  • Author: Julie B Zhao, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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For the immunocompetent host, histoplasmosis is frequently asymptomatic or self-­limited. In the setting of HIV/AIDS, this infection is much more common and frequently progresses to disseminated disease.

This infection is endemic to certain areas of the United States, particularly in states bordering the Ohio River valley and the lower Mississippi River.

Spores of the mold phase are inhaled and cause a localized or patchy bronchopneumonia. CD4 lymphocytes normally activate macrophages to control the infection. [27]

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