Which immunocompromised patients have the highest incidence of aspergillus pneumonia?

Updated: Jan 07, 2019
  • Author: Julie B Zhao, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Answer

Invasive aspergillus pneumonia is one of the four aspergillosis syndromes that primarily affects immunosuppressed individuals.

In solid organ and hematopoietic transplant patients, there is a bimodal distribution of incidence with peaks during 1. prolonged neutropenia before engraftment and 2. in later stages with corticosteroid therapy in treatment of graft-versus-host disease.

Patients with leukemia and lymphoma have a higher incidence of invasive aspergillosis which is associated with a higher mortality rate. [23]

Invasive aspergillosis is also being increasingly observed in patients with severe COPD who remain on long-term corticosteroid therapy. [24]

There are no reliable biomarkers for detection of fungal cell wall constituents or other specific measures, thus, the recommendation continues to be close monitoring of clinical signs and symptoms for prevention and prophylaxis of opportunistic fungal pneumonias. [25]


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