How is protein assessment of CSF from lumbar puncture (LP) used in the diagnosis of neurologic disease?

Updated: Aug 02, 2018
  • Author: Gil Z Shlamovitz, MD, FACEP; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Assessment of CSF protein level, though nonspecific, can be a clue to otherwise unsuspected neurologic disease. The high protein levels in demyelinating polyneuropathies, or postinfectious states, can be informative. A traumatic tap can introduce protein into the CSF. An approximation of 1 mg of protein for every 750 RBCs may be used, but a repeat tap is preferable.


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