What is included in the workup of Reye syndrome?

Updated: Apr 02, 2018
  • Author: Debra L Weiner, MD, PhD; Chief Editor: Kirsten A Bechtel, MD  more...
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Answer

Workup to exclude inborn errors of metabolism (IEMs) must be performed and should include evaluation for defects of fatty-acid oxidation, amino and organic acidurias, urea-cycle defects, and disorders of carbohydrate metabolism. Various invasive procedures may be indicated. Computed tomography (CT) of the head may reveal cerebral edema, but the results are usually normal. Electroencephalography (EEG) may reveal slow-wave activity in the early stages and flattened waves in advanced stages. MRI characteristics of Reye syndrome are symmetric thalamic, white matter and basal ganglia lesions, in children with recent history of salycilates or immunosuppressive drugs intake. [9]


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