What are the risk factors for Reye syndrome mortality?

Updated: Apr 02, 2018
  • Author: Debra L Weiner, MD, PhD; Chief Editor: Kirsten A Bechtel, MD  more...
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Answer

Increased risk of mortality is associated with the following:

  • Age younger than 5 years, with a relative risk of 1.8 (95% CI, 1.5-2.1)

  • Rapid progression from stage 1 to stage 3 and/or presentation with stage 4 or 5 (See Physical Examination) - The death rate by stage at the time of admission is 18% for patients in stage 0 and 90% for those in stage 5; meaningful survival beyond stage 3 is unlikely; full recovery is possible for patients in stages 0-2

  • Central venous pressure (CVP) less than 6 mm H2 0

  • Ammonia level greater than 45 µg/dL (26 µmol/L), with a relative risk of 3.4 (95% CI, 1.9-6.2) [4]

  • Glucose value less than 60 mg/dL

  • Hypoproteinemia unresponsive to fresh frozen vitamin K and fresh frozen plasma (FFP)

  • Muscle involvement

  • Antecedent diarrheal illness


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