What are the signs and symptoms of toxicity in pediatric patients with fever?

Updated: Jul 23, 2019
  • Author: Hina Z Ghory, MD; Chief Editor: Russell W Steele, MD  more...
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Toxicity is defined as a clinical syndrome with the following: lethargy with (1) poor perfusion as evidenced by delayed capillary refill or (2) cyanosis or other signs of respiratory distress. Cold hands and feet, limb pain, and pale or mottled skin are considered "red flag" manifestations of septicemia. [34]

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