What is the role of pharmacologic therapy in the treatment of pediatric dehydration?

Updated: Nov 12, 2018
  • Author: Alex Koyfman, MD; Chief Editor: Muhammad Waseem, MS, MBBS, FAAP, FACEP, FAHA  more...
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The emergency medicine literature now supports the use of a single dose of oral ondansetron in combination with oral rehydration for patients with dehydration, nausea, and vomiting. [12, 15, 16] However, the use of an antiemetic should not shift the focus away from adequate fluid resuscitation.

Acute gastroenteritis is typically a self-limited condition that does not require antibiotics. [17] Chronic infectious cases of diarrhea may require antimicrobial agents after appropriate stool studies have indicated the etiology. [18] Antidiarrheal agents are not recommended. When dehydration is caused by other disease processes, such as diabetic ketoacidosis or sepsis, appropriate pharmacologic therapy should be initiated as soon as possible.

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